About Cord Blood:
Cord blood, which is also called "placental blood," is the blood
that remains in the umbilical cord and placenta following birth and
after the cord is cut. Cord blood is routinely discarded with the
placenta and umbilical cord.
Your baby's umbilical cord blood is a valuable
source of stem cells, which are genetically unique to your baby
and family.
About Stem Cell:
Stem cells are the body's "master" cells because they
create all other tissues, organs, and systems in the body. The
stem cells found in cord blood are the building blocks of your
blood and immune system and most readily reproduce into:
Red Blood Cells - which carry oxygen to all the cells in the
body
White Blood Cells - which fight infection
Platelets - which aid in clotting in the event of injury
There are three sources where stem cells are commonly found,
they are:
Bone Marrow
Peripheral Blood (the blood that circulates through your body)
Umbilical Cord Blood
The ability of cord blood stem cells to differentiate, or
change into other types of cells in the body is a new discovery
that holds significant promise for improving the treatment of
some of the most common diseases such as heart disease, stroke,
and Alzheimer's.
Today, stem cell therapy is a
major breakthrough in regenerative medical research. Stem cells
have the potential to help cure many life-threatening ailments
like leukemia, non-Hodgkin's lymphoma, anemia, inherited
disorders and all other deficiencies of the immune system.
Lifestyle diseases such as diabetes, liver disorders and heart
ailments can also be treated with stem cells.
The Advantage
Cord blood stem cells have many significant advantages over
other sources of stem cells like bone marrow. Cord blood stem
cells are:
-
More tolerant of tissue mismatches
-
Have a lower risk of severe graft-vs-host
disease (a major complication in stem cell transplants)
-
Rarely contaminated with latent viruses
Cord blood is also "privileged" or unexposed to most diseases
that make bone marrow from an adult more difficult to use in
transplantation.
More importantly, cord blood from your baby is a perfect match
for your child, if it ever should be needed, and has a 1 - in -
4 chance of matching a current or future sibling. Childbirth is
thus a once-in-a-lifetime opportunity to collect and preserve
these stem cells and harness what is otherwise discarded as
bio-medical waste.
So, when you preserve your baby's cord blood stem cells, you
ensure your family the gift of life.
Processing Cord Blood
the stem cells are separated from the red blood cells and plasma
instead of freezing the blood as a whole. This method produces
cells with greater viability and is preferred by Physicians,
because it minimizes the risk of blood type (ABO)
incompatibility later.
Once the stem cells are separated from the red blood cells and
plasma, they are placed in 5ml cryovials in preparation for
freezing and storage. The designated Cord Blood registry uses a
small amount of your baby's own plasma and Dimethyl Sulfoxide
(DMSO) to protect the cells. The DMSO solution can be spun out
of the cell in the future, when it is needed for transplant.
Your baby's cord blood sample is stored in multiple cryovials.
On an average, we store cryovials of each cord blood sample.
This provides the families a significant benefit in the future,
since the cells may be used for more than one treatment.
Each vial is bar coded and clearly marked with: Cord Blood
Identifying Number, Account Number, Date of Processing and
Contents. Each vial is individually wrapped using a cryo
sheathing to protect against cross-contamination. Your vials
then enter the first stage of the cryopreservation, with a
slow-rate introduction to the freezing process. Most of the
present day Cord Blood Registry uses this technique of slow-rate
introduction to ensure the safety of the cells. The progression
to lower and lower temperatures keeps the cells from going into
shock from the extreme negative temperature of -196° Celsius.
Screening
Your cord blood sample is tested for bacterial and fungal
infections when it arrives at the Cord Blood Registry lab. All
expectant mothers will be sending 2 vials of blood (included in
the kit) with the baby's cord blood sample, to facilitate
testing the blood for infectious disease markers. This is a
mandatory requirement of cord blood banking regulations.
Storage
Your baby's cells are secure at Cord Blood Registry
state-of-the-art storage facility, which is monitored 24 hours a
day with a high-tech alarm system and back-up generators. Our
computer system constantly monitors and tracks your vials at all
times. You can rest assured that your baby's cord blood is in
the hands of Cord Blood Registry's experienced laboratory and
cellular storage personnel.
Cord blood stem cells are preferred over bone marrow stem cells
(for transplantation) and have already been used to treat
numerous types of malignancies including certain kinds of
leukemia, Hodgkin's disease and other types of lymphoma. It has
also been used for the treatment of a variety of anemia,
inherited metabolic disorders and deficiencies of the immune
system.
Umbilical cord blood stem cell was first used for transplantation
in 1988, in France, for a patient with Fanconi's anemia. Since that
time, cord blood stem cell has been increasingly used as a
substitute for bone marrow in thousand of successful transplants.
Cord blood stem cell transplants are known to be as successful as bone
marrow in the cases in which they have been used. Moreover cord
blood has other advantages over bone marrow, including ease of
collection and better tolerance of HLA mismatches. |